Timing of eating

Adults who ate their first meal before 8:30 a.m. each day had lower insulin resistance compared with those who started eating after 8:30 a.m., independent of eating interval duration. “The timing of eating is also an important consideration in addition to duration of eating,” “Our internal biological clocks that control rhythms related to metabolic health play a vital role at the intersection of nutrition and lifestyle that impact metabolic health. Timing of eating was associated with metabolic measures, including insulin resistance, and is a potential area for intervention to combat the increase in metabolic disorders like diabetes.” Analyzed data from two nonconsecutive dietary…

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Benefits of cell therapy for type 1 diabetes outweigh risks

The investigational cell therapy donislecel demonstrated a favorable risk-benefit profile for certain patients with difficult-to-control type 1 diabetes. There is nothing patients [with diabetes] like more than freedom from dealing with the entire insulin issue. This therapy can help some patients and will be incredibly meaningful to those who receive it. Donislecel (Lantidra, CellTrans) — an allogeneic pancreatic islet cellular therapy — has been shown to increase insulin independence and decrease the number of severe hypoglycemic events among patients with difficult-to-control type 1 diabetes, based…

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GLP-1 receptor agonists ‘superior’ for countering weight regain after bariatric surgery

Adults with obesity who regained weight after bariatric surgery saw more effective weight loss with GLP-1 receptor agonist therapy compared with other weight-loss regimens. There are several medications that are approved for weight management (phentermine, topiramate-phentermine, orlistat, bupropion-naltrexone and liraglutide); however, there are limited data to support their use to treat post-bariatric weight regain. Liraglutide is a GLP-1 receptor agonist that is approved for managing type 2 diabetes mellitus and obesity. Studies have shown that postprandial levels of endogenous GLP-1 after bariatric surgery can be…

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Orlistat Therapy for Obesity Linked to Fewer Major Adverse Cardiovascular Events

People with obesity using orlistat for weight loss may benefit from lower rates of overall major cardiovascular events, new-onset heart failure, renal failure, and mortality. Because diet and lifestyle measures can have variable and limited effects on the initial management of obesity and bariatric surgery remains an invasive and expensive option, pharmacologic weight loss agents provide another weight-loss alternative for individuals with obesity. Orlistat, a lipase inhibitor, is 1 of 4 agents approved by the US Food and Drug Administration and the only drug licensed for…

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Invokana ( Dapagliflozin ) Cardiovascular and Renal Benefit .

The sodium-glucose co-transporter 2 inhibitor (SGLT2i) dapagliflozin has consistent cardiovascular benefits across baseline kidney-function and albuminuria levels in high-risk patients with type-2 diabetes mellitus (T2DM) Dapagliflozin consistently reduced the relative risk of cardiovascular events irrespective of baseline estimated glomerular filtration rate (eGFR) and albuminuria status in a broad population of patients with T2DM. SGLT2is promote urinary glucose excretion and reduce the risk for cardiovascular death and hospitalizations for heart failure in patients with T2DM. However, The extent of increased glycosuria and, therefore, the glucose-lowering efficacy…

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FDA approves once-weekly Semaglutide for weight loss

The FDA approved once-weekly semaglutide injection for chronic weight management in adults with obesity or with overweight and at least one weight-related condition Weekly semaglutide 2.4 mg (Wegovy, Novo Nordisk), a GLP-1 receptor agonist, is the first-approved drug for chronic weight management in adults with general obesity or overweight since 2014. Semaglutide is indicated for chronic weight management in adults with a BMI of 27 kg/m² or greater who have at least one weight-related comorbidity, such as type 2 diabetes or hypertension, or in adults…

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FDA OKs Injectable Semaglutide for Chronic Weight Management

The FDA approved Novo Nordisk's injectable semaglutide (Wegovy) for adults with obesity or overweight. The GLP-1 receptor was approved for chronic weight management in adults with obesity (BMI of 30 or greater) or for adults with overweight (BMI 27 or greater) with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol, used in conjunction with a reduced calorie diet and an exercise regimen. The once-weekly, injectable medication is approved at a dose of 2.4 mg for this indication.…

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When to eat for better workout

For those looking to get the most out of their workouts, deciding what and when to eat can be difficult. As anyone who has scarfed down a big meal right before hitting the gym knows, timing matters. Most people need roughly 0.8 g of protein per kilogram of body weight per day, which translates to about 55 g of protein for someone who weighs 150 lbs. Even if you’re looking to build muscle, research suggests that consuming 20-40 g of protein at a time (roughly the…

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Maternal eating habits may affect children’s weight later in life

Maternal nutrition during pregnancy may have a long-term impact on children’s weight trajectories, researchers reported. Previous studies have largely examined the relationship between a woman’s diet during pregnancy and its impact on offspring BMI trajectories during the neonatal and early-childhood periods.Children of women who have low adherence to a Mediterranean diet have higher BMI z-scores from ages 3 to 15 years.Healthy eating during pregnancy is very important and always recommended.

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