GLP-1 receptor agonists ‘superior’ for countering weight regain after bariatric surgery

Adults with obesity who regained weight after bariatric surgery saw more effective weight loss with GLP-1 receptor agonist therapy compared with other weight-loss regimens.

There are several medications that are approved for weight management (phentermine, topiramate-phentermine, orlistat, bupropion-naltrexone and liraglutide); however, there are limited data to support their use to treat post-bariatric weight regain.

Liraglutide is a GLP-1 receptor agonist that is approved for managing type 2 diabetes mellitus and obesity. Studies have shown that postprandial levels of endogenous GLP-1 after bariatric surgery can be 10 to 20 times higher compared with before surgery.”

Finally, Researchers found the results don’t change when stratified by bariatric surgery type, adding that treatment group is the only significant predictor of percentage weight change.

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Ali Achira MD

Dr. Ali Achira Dr. Ali Achira, MD is an endocrinologist in Dearborn and in Taylor, Michigan. He is currently licensed to practice medicine in Michigan. He is affiliated with DMC Harper University Hospital. He is board certified in Internal Medicine. Board certified in Endocrinology & Diabetes, and board certified in Obesity medicine. He manages Diabetes, Thyroid, osteoporosis, Obesity and other endocrinology disorders.